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    Email: marketing@medicilon.com.cn

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Customer Center
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Jun 28,2023
Éè¼ÆºÏ³ÉһϵÁÐDHODHÒÖÖƼÁ×÷ΪDZÔÚµÄÀà·çʪÐÔÊàŦÑ×ÖÎÁÆÒ©ÎPKÑо¿Í¨¹ý×ðÁú¿­Ê±¾ÙÐÐ
Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases. Herein, researchers designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential rheumatoid arthritis (RA) treatment agents.
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Éè¼ÆºÏ³ÉһϵÁÐDHODHÒÖÖƼÁ×÷ΪDZÔÚµÄÀà·çʪÐÔÊàŦÑ×ÖÎÁÆÒ©ÎPKÑо¿Í¨¹ý×ðÁú¿­Ê±¾ÙÐÐ
Jun 28,2023
¿ª·¢²¢Ñé֤еÄLC-MS/MSÒªÁ죬ÓÃÓÚ¶¨Á¿ÈËѪ½¬ÖдïÀ­·ÇÄá¼°ÆäÖ÷Òª´úлÎïôÇ»ù´ïÀ­·ÇÄá (OHD)¡£OHD£¨´¿¶È>99%£©Í¨¹ý×ðÁú¿­Ê±ºÏ³É
OHD (purity >99 %) was synthesized by Medicilon. Medicilon synthetic chemistry team is capable of the independent design of synthesis pathways and complex compound treatments, key to helping accelerate drug discovery.
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¿ª·¢²¢Ñé֤еÄLC-MS/MSÒªÁ죬ÓÃÓÚ¶¨Á¿ÈËѪ½¬ÖдïÀ­·ÇÄá¼°ÆäÖ÷Òª´úлÎïôÇ»ù´ïÀ­·ÇÄá (OHD)¡£OHD£¨´¿¶È>99%£©Í¨¹ý×ðÁú¿­Ê±ºÏ³É
Jun 28,2023
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Radiation therapy is used as the primary treatment for lung cancer. In this study, radiation therapy for establish ionizing radiation-resistant lung cancer cell lines (A549-IR/H1299-IR) was supported by Medicilon.
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Jun 28,2023
CAR-TÁÆ·¨Ö÷ÒªÕë¶Ô°×Ѫ²¡Óë¶ñÐÔÁÜ°ÍÁö£¬´ËÑо¿Öй¹½¨Ä¬È»PD-1µÄshRNAÔØÌåÖÊÁ££¬²âÐòºóÖÊÁ£µÄÅжÏͨ¹ý×ðÁú¿­Ê±¾ÙÐÐ
Chimeric antigen receptor T cells (CAR-T) immunotherapy has shown promising clinical results in the treatment of leukemia and lymphoma, but the effectiveness is limited for solid tumors. The shRNA vector plasmid that silences PD-1 and preparation of CAR is constructed. The plasmids sequenced were fully identified by Medicilon.
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CAR-TÁÆ·¨Ö÷ÒªÕë¶Ô°×Ѫ²¡Óë¶ñÐÔÁÜ°ÍÁö£¬´ËÑо¿Öй¹½¨Ä¬È»PD-1µÄshRNAÔØÌåÖÊÁ££¬²âÐòºóÖÊÁ£µÄÅжÏͨ¹ý×ðÁú¿­Ê±¾ÙÐÐ
Jun 28,2023
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The SOR ASD tablets exhibited approximately 50% higher relative bioavailability in dogs than the marketed SOR tablet product, Nexavar?. The pharmacokinetic (PK) study of SOR ASD tablets and Nexavar? tablets was performed by Medicilon.
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Jun 28,2023
TAK-931ÊÇÒ»Öָ߶ÈÌØÒìÐÔµÄCDC7ÒÖÖƼÁ£¬¾ßÓп¹Ö×Áö¹¦Ð§£¬ÌåÄÚҩЧÑо¿Í¨¹ý×ðÁú¿­Ê±¾ÙÐÐ
In vivo efficacy studies in J558 allograft models in combination with anti-mPD-1, anti-mPD-L1, and anti-mCTLA-4 antibodies were performed at Medicilon.
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TAK-931ÊÇÒ»Öָ߶ÈÌØÒìÐÔµÄCDC7ÒÖÖƼÁ£¬¾ßÓп¹Ö×Áö¹¦Ð§£¬ÌåÄÚҩЧÑо¿Í¨¹ý×ðÁú¿­Ê±¾ÙÐÐ
Jun 28,2023
GS-5801ÊÇÒ»ÖÖÓÐÓõÄKDM5ÒÖÖƼÁ£¬¾ßÓп¹HBV»îÐÔ£¬GS-5801ͨ¹ý×ðÁú¿­Ê±ºÏ³É
GS-5801, a potent inhibitor of KDM5, has antiviral activity against HBV in a primary human hepatocytes infection model, with the cellular permeability, oral bioavailability. GS-5801 was synthesized by Medicilon.
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GS-5801ÊÇÒ»ÖÖÓÐÓõÄKDM5ÒÖÖƼÁ£¬¾ßÓп¹HBV»îÐÔ£¬GS-5801ͨ¹ý×ðÁú¿­Ê±ºÏ³É
Jun 28,2023
QF-036ÊÇÒ»ÖÖ¸ßЧµÄHIV-1ÒÖÖƼÁ£¬¾ßÓÐÓÅÒìµÄºÍÒ©´ú¶¯Á¦Ñ§ÌØÕ÷£¬PKÑо¿Í¨¹ý×ðÁú¿­Ê±¾ÙÐÐ
The favourable viral inhibitory activity and pharmacokinetic properties provide critical support for QF-036 as a promising anti-HIV therapeutic candidate. The pharmacokinetic studies were performed by Medicilon.
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QF-036ÊÇÒ»ÖÖ¸ßЧµÄHIV-1ÒÖÖƼÁ£¬¾ßÓÐÓÅÒìµÄºÍÒ©´ú¶¯Á¦Ñ§ÌØÕ÷£¬PKÑо¿Í¨¹ý×ðÁú¿­Ê±¾ÙÐÐ
Jun 28,2023
Éè¼ÆºÏ³ÉÒ»ÖÖÐÂÐÍÑ¡ÔñÐԵĿڷþÓÐÓÃËÕ°±ËáÀÒ°±Ëἤø (TTK) ÒÖÖƼÁ£¬PKÑо¿¾ùͨ¹ý×ðÁú¿­Ê±¾ÙÐÐ
TTK inhibition is an attractive wide-spectrum strategy for cancer therapy. Researchers designed and synthesized a series of pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable TTK inhibitors. All the pharmacokinetic studies were carried out by Medicilon.
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Éè¼ÆºÏ³ÉÒ»ÖÖÐÂÐÍÑ¡ÔñÐԵĿڷþÓÐÓÃËÕ°±ËáÀÒ°±Ëἤø (TTK) ÒÖÖƼÁ£¬PKÑо¿¾ùͨ¹ý×ðÁú¿­Ê±¾ÙÐÐ
Jun 28,2023
TR-107ÊÇÈËÀàÏßÁ£ÌåÂÑ°×øClpPµÄÓÐÓü¤»î¼Á£¬PKÆÊÎöͨ¹ý×ðÁú¿­Ê±¾ÙÐÐ
The pharmacokinetic properties of TR©\107 were compared with other known ClpP activators including ONC201 and ONC212. TR©\107 displayed excellent exposure and serum t1/2 after oral administration. Pharmacokinetic analysis were evaluated for pharmacokinetic properties in ICR mice by Medicilon.
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TR-107ÊÇÈËÀàÏßÁ£ÌåÂÑ°×øClpPµÄÓÐÓü¤»î¼Á£¬PKÆÊÎöͨ¹ý×ðÁú¿­Ê±¾ÙÐÐ
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